I thought this was a fantastic article describing the relationship between obesity and Alzheimer’s Disease. AD was once thought to be a “progressive neurodegenerative disease,” meaning that it was essentially a slow breakdown of the structures and neurons within the brain. With new information regarding potential risk factors, modifiable risk factors at that, we can now work to prevent this disease from occurring as frequently. Follow Oncotarget on Twitter.
This article specifically looked at body weight, blood glucose, and insulin levels prior to “sacrifice.” The test rats were given a high-fat diet, which triggered oxidative stress and mitochondrial dysfunction. This led to them being found with a higher body weight and a decreased cerebral weight, signaling the loss of brain volume. The article conclusion essentially states that targeting individuals who are considered obese and working with them to reduce their body weight may also help prevent issues in the brain later in life. Learn more at researchgate.net
Oncotarget has also been researching new ways to treat thyroid cancer. One of the most promising is the use of a combination of traditional cancer drugs. The drugs are palbociclib and vemurafenib, and their combined effect is enough to produce desired effects in the patient. Instead of the patient building up resistance to the drugs individually, they are able to take smaller and more synergistic doses.
Lastly, the Oncotarget podcast is available to listen to from Stitcher, Player.FM and iTunes. The health issues already mentioned, plus several more will be discussed, along with testimonials, publication ethics, and publication malpractice.